1,255 research outputs found
Autonomous decision-making against induced seismicity in deep fluid injections
The rise in the frequency of anthropogenic earthquakes due to deep fluid
injections is posing serious economic, societal, and legal challenges to
geo-energy and waste-disposal projects. We propose an actuarial approach to
mitigate this risk, first by defining an autonomous decision-making process
based on an adaptive traffic light system (ATLS) to stop risky injections, and
second by quantifying a "cost of public safety" based on the probability of an
injection-well being abandoned. The ATLS underlying statistical model is first
confirmed to be representative of injection-induced seismicity, with examples
taken from past reservoir stimulation experiments (mostly from Enhanced
Geothermal Systems, EGS). Then the decision strategy is formalized: Being
integrable, the model yields a closed-form ATLS solution that maps a risk-based
safety standard or norm to an earthquake magnitude not to exceed during
stimulation. Finally, the EGS levelized cost of electricity (LCOE) is
reformulated in terms of null expectation, with the cost of abandoned
injection-well implemented. We find that the price increase to mitigate the
increased seismic risk in populated areas can counterbalance the heat credit.
However this "public safety cost" disappears if buildings are based on
earthquake-resistant designs or if a more relaxed risk safety standard or norm
is chosen.Comment: 8 pages, 4 figures, conference (International Symposium on Energy
Geotechnics, 26-28 September 2018, Lausanne, Switzerland
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Weight management during teenage pregnancy: Issues to consider when developing appropriate support
Teenage pregnancy is more prevalent in areas of high obesity, compared to areas where obesity levels are low. Risks associated with maternal obesity in pregnant teenagers include pre-eclampsia and caesarean delivery. To reduce these risks, pregnant teenagers need to be supported to gain a healthy weight in pregnancy. This includes encouraging these women to eat healthily through providing appropriate information including online or smartphone apps in conjunction with face-to-face support. These young women also need encouragement to be physically active. This support must be tailored to the teenage population considering their specific barriers and facilitators to behaviour change. Midwives with the aid of a multidisciplinary team play a key role in encouraging these healthy behaviours
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Different Verbal Learning Strategies in Autism Spectrum Disorder: Evidence from the Rey Auditory Verbal Learning Test
The Rey Auditory Verbal Learning Test, which requires the free recall of the same list of 15 items over 5 trials, was administered to a group of highfunctioning adolescents and adults with autism spectrum disorder (PDD) and a group of matched typical individuals. Overall levels of free recall were comparable in the two groups, as were the rates of learning over trials. Both groups also subjectively organised their recall to a similar extent. However, the serial position curve of the PDD participants, although similar to that of the comparison group on the first trial, became flatter on subsequent trials and was characterised by a slower growth in the primacy effect. Growth in the middle and recency portions of the curve was comparable in both groups. The findings are discussed in the light of current models of serial position effects and their implications for memory in ASD
The conserved C-terminus of the PcrA/UvrD helicase interacts directly with RNA polymerase
Copyright: © 2013 Gwynn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by a Wellcome Trust project grant to MD (Reference: 077368), an ERC starting grant to MD (Acronym: SM-DNA-REPAIR) and a BBSRC project grant to PM, NS and MD (Reference: BB/I003142/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity
The Wnt family of proteins are secreted signaling proteins that play key roles in regulating cellular functions. Recently, carboxylesterase Notum was shown to act as a negative regulator of Wnt signaling by mediating the removal of an essential palmitoleate. Here we disclose two new chemical scaffolds that inhibit Notum enzymatic activity. Our approach was to create a fragment library of 250 acids for screening against Notum in a biochemical assay followed by structure determination by X-ray crystallography. Twenty fragments were identified as hits for Notum inhibition, and 14 of these fragments were shown to bind in the palmitoleate pocket of Notum. Optimization of 1-phenylpyrrole 20, guided by structure-based drug design, identified 20z as the most potent compound from this series. Similarly, the optimization of 1-phenylpyrrolidine 8 gave acid 26. This work demonstrates that inhibition of Notum activity can be achieved by small, drug-like molecules possessing favorable in vitro ADME profiles
Updated Three-Stage Model for the Peopling of the Americas
Background: We re-assess support for our three stage model for the peopling of the Americas in light of a recent report that identified nine non-Native American mitochondrial genome sequences that should not have been included in our initial analysis. Removal of these sequences results in the elimination of an early (i.e.,40,000 years ago) expansion signal we had proposed for the proto-Amerind population. Methodology/Findings: Bayesian skyline plot analysis of a new dataset of Native American mitochondrial coding genomes confirms the absence of an early expansion signal for the proto-Amerind population and allows us to reduce the variation around our estimate of the New World founder population size. In addition, genetic variants that define New World founder haplogroups are used to estimate the amount of time required between divergence of proto-Amerinds from the Asian gene pool and expansion into the New World. Conclusions/Significance: The period of population isolation required for the generation of New World mitochondrial founder haplogroup-defining genetic variants makes the existence of three stages of colonization a logical conclusion. Thus, our three stage model remains an important and useful working hypothesis for researchers interested in the peopling of th
Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis
BACKGROUND: Ulcerative colitis (UC) and Crohn's disease (CD) are characterized by intestinal inflammation mainly caused by a disturbance in the balance between cytokines and increased complement (C) activation. Our aim was to evaluate possible associations between C activation capacity and prednisolone treatment. METHODS: Plasma from patients with exacerbations of UC (n = 18) or CD (n = 18) were collected before and during high dose prednisolone treatment (1 mg/kg body weight) and tapering. Friedman's two way analysis of variance, Mann-Whitney U test and Wilcoxon signed-rank sum test were used RESULTS: Before treatment, plasma from CD patients showed significant elevations in all C-mediated analyses compared to the values obtained from 38 healthy controls (p < 0.02), and in mannan binding lectin (MBL)-concentration and MBL-C4-activation capacity (AC) values compared to UC patients (p < 0.02). Before treatment, plasma from UC patients showed significant elevations only in the classical pathway-mediated C3-AC compared to values obtained from healthy controls (p < 0.01). After treatment was initiated, significant reductions, which persisted during follow-up, were observed in the classical pathway-mediated C3-AC and MBL-C4-AC in plasma from CD patients (p < 0.05). CONCLUSION: Our findings indicate that C activation capacity is up-regulated significantly in plasma from CD patients. The decreases observed after prednisolone treatment reflect a general down-regulation in immune activation
Computing the common zeros of two bivariate functions via BĂ©zout resultants
The common zeros of two bivariate functions can be computed by finding the common zeros of their polynomial interpolants expressed in a tensor Chebyshev basis. From here we develop a bivariate rootfinding algorithm based on the hidden variable resultant method and BĂ©zout matrices with polynomial entries. Using techniques including domain subdivision, BĂ©zoutian regularization, and local refinement we are able to reliably and accurately compute the simple common zeros of two smooth functions with polynomial interpolants of very high degree (â„ 1000). We analyze the resultant method and its conditioning by noting that the BĂ©zout matrices are matrix polynomials. Two implementations are available: one on the Matlab Central File Exchange and another in the roots command in Chebfun2 that is adapted to suit Chebfunâs methodology
Reactive community-based self-administered treatment against residual malaria transmission: study protocol for a randomized controlled trial
Background: Systematic treatment of all individuals living in the same compound of a clinical malaria case may
clear asymptomatic infections and possibly reduce malaria transmission, where this is focal. High and sustained
coverage is extremely important and requires active community engagement. This study explores a communitybased
approach to treating malaria case contacts.
Methods/design: This is a cluster-randomized trial to determine whether, in low-transmission areas, treating
individuals living in the same compound of a clinical malaria case with dihydroartemisinin-piperaquine can reduce
parasite carriage and thus residual malaria transmission. Treatment will be administered through the local health
system with the approach of encouraging community participation designed and monitored through formative
research. The trial goal is to show that this approach can reduce in intervention villages the prevalence of
Plasmodium falciparum infection toward the end of the malaria transmission season.
Discussion: Adherence and cooperation of the local communities are critical for the success of mass treatment
campaigns aimed at reducing malaria transmission. By exploring community perceptions of the changing trends in
malaria burden, existing health systems, and reaction to self-administered treatment, this study will develop and
adapt a model for community engagement toward malaria elimination that is cost-effective and fits within the
existing health system.
Trial registration: Clinical trials.gov, NCT02878200. Registered on 25 August 2016
Observation of associated near-side and away-side long-range correlations in âsNN=5.02ââTeV proton-lead collisions with the ATLAS detector
Two-particle correlations in relative azimuthal angle (ÎÏ) and pseudorapidity (Îη) are measured in âsNN=5.02ââTeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1ââÎŒb-1 of data as a function of transverse momentum (pT) and the transverse energy (ÎŁETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Îη|<5) ânear-sideâ (ÎÏâŒ0) correlation that grows rapidly with increasing ÎŁETPb. A long-range âaway-sideâ (ÎÏâŒÏ) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ÎŁETPb, is found to match the near-side correlation in magnitude, shape (in Îη and ÎÏ) and ÎŁETPb dependence. The resultant ÎÏ correlation is approximately symmetric about Ï/2, and is consistent with a dominant cosâĄ2ÎÏ modulation for all ÎŁETPb ranges and particle pT
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